A great collaboration with Stefania Millevoi @ CRCT-Oncopole (Toulouse, France) is now out in Nucleic Acids Research. In this work, we present QUADRatlas (https://rg4db.cibio.unitn.it), a database of experimentally-derived and computationally predicted RNA G-quadruplex (RG4s) in the human transcriptome, enriched with biological function and disease associations.
We mined known interactions of RG4s with such proteins, complemented with an extensive RBP binding sites dataset. Users can thus intersect RG4s with their potential regulators and effectors, enabling the formulation of novel hypotheses on RG4 regulation, function and pathogenicity. To support this capability, we provide analysis tools for predicting whether an RBP can bind RG4s, RG4 enrichment in a gene set, and de novo RG4 prediction. Genome-browser and table views allow exploring, filtering, and downloading the data quickly for individual genes and in batch.
QUADRatlas: the RNA G-quadruplex and RG4-binding proteins database.
Sébastien Bourdon, Pauline Herviou, Leïla Dumas, Eliana Destefanis, Andrea Zen, Anne Cammas, Stefania Millevoi, Erik Dassi.
Nucleic Acids Research, 2023. https://doi.org/10.1093/nar/gkac782
The paper is open access and can be found here.
Dassi Lab 